I didn't think this could get any more extreme or weird, but the Japanese mass entertainment industry must be meeting some sort of demand for this.
Hatsune Miku’s Vocaloid Opera "The End" to Debut in Paris
TRAILER / VOCALOID OPERA “THE END” ARTIST INTERVIEW
Louis Vuitton Designs Hatsune Miku's Costume for Opera
wiki - Hatsune Miku